PROFILING BIOACTIVE COMPOUNDS IN CARICA PAPAYA L. USING GC-MS FOR SICKLE CELL DISEASE MANAGEMENT

Abstract

Carica papaya L. plant have potential phytochemical compound that help into the management of sickle cell disease. The present study investigated the bioactive component responsible for sickle cell disease management in the methanol extract of the unripe fruit of Carica papaya L. This extract of unripe fruit phytochemical was identified by GC-MS using a library search. A total 54 phyto-component were identified and 07 are directly related to sickle cell disease management. The main bioactive component present in methanolic extract are piracetam, 4H-Pyran-4-one, 2,3-dihydro-3,5dihydroxy-6-methyl-,(S)-5-Hydroxymethyl-2[5H]-furanone, Pterin-6-carboxylic acid, L-(+)-Ascorbic acid 5,6-dihexadecanoaten, 10(E),12(Z)-Conjugated linoleic acid, 9(E), 11(E)- Conjugated linoleic acid in term of their role and action with management sickle cell anemia, Other antioxidant compounds identified in the GC-MS analysis could play a significant role in  future clinical trials for management of sickle cell disease.