Effect of Endosulfan on ATPase Activity in Liver, Kidney and Muscles of Channa punctatus and Their Recovery Response

Abstract

The specific activities of Na+-K+ ATPase and Mg++ ATPase were investigated in liver, kidney and muscles of a fresh water fish, Channa punctatus at the interval of 15 and 30 days exposure to 1/5th of 96 hours TLm of endosulfan, i.e., 0.00033 mg/l. The activities were found to be inhibited significantly. The recovery response of adverse effects of the exposure was also carried out. The inhibition in activity of Na+-K+ ATPase after 15 days exposure was 37.56%, 31.65% and 34.34% which was recovered after 15 days in toxicant free water up to the levels of 12.24%, 8.68% and 11.17% in liver, kidney and muscles, respectively The activity of Mg++ ATPase was inhibited by 41.28%, 38.42% and 39.85% which was found to be recovered up to 13.38%, 11.21% and 12.72%in the liver, kidney and muscles respectively. The activity of Na+-K+ ATPase after 30 days exposure was inhibited to 52.79%, 43.63% and 51.11% and after 30 days in normal water that was recovered up to 14.89%, 10.67% and 14.37% and inhibition of Mg++ ATPase was found to be 63.86%, 58.26% and 59.79% and after recovery it was found to be 13.11%, 10.33% and 12.15% in liver, kidney and muscles respectively. The order of inhibition in the activity of ATPase was found to be liver>muscles>kidney and the order of recovery of the activity of ATPase was found to be contradictory like kidney>muscles>liver. This alteration in the activity of ATPase may alter cellular metabolism which may in turn result to reallocate the fish physiology.