Histo-Pathological Alterations Associated Metabolic Alterations in STZ Induced Diabetic Rats with Leaves Extract of Sapindus saponaria

Abstract

In the present study oral administration of aqueous extract of Sapindus saponaria (SS) to streptozotocin (STZ) induced diabetic rats secluded the rats from the changes in Histopathological tissues of rats. STZ induces diabetes that resembles human hyperglycemic non-ketotic diabetes mellitus. Further rats treated with STZ display many of the features in human subjects with uncontrollable DM and are invaluable when studying the mechanisms by which hyperglycemia may contribute to microvascular complications such as neuropathy, nephropathy and retinopathy. The functioning of pancreas, liver and kidney may be affected due to decreased levels of insulin, hyperglycemia and its consequences. In the present investigation the histological changes in these tissues of diabetic rats and the effect of Sapindus saponaria SS aqueous extract on these was studied.