Effects of Pb2+ and Cd2+ Heavy Metal Ions on the Rat Liver Mitochondrial ATP-Dependent Potassium Channel

Abstract

In the article, rat liver of Pb2+ and Cd2+ ionsthe effect on mitoKATP-channel activity in mitochondria was studied.Inhibition of mitoKATF-channel activity was observed experimentally in the presence of 200 μM concentration of ATP in the incubation medium of mitochondria isolated from rat liver.In the absence of ATP in the incubation medium, 8.0 µM concentration of Pb2+ and Cd2+ salts was noted to reduce the permeability of liver mitoKATP-channel activity in both energized and de-energized states compared to the control.