NAPHTHOQUINONE DERIVATIVES AS MULTIFUNCTIONAL AGENTS: FROM ANTIOXIDANTS TO ANTICANCER THERAPIES

Abstract

Naphthoquinone derivatives have garnered significant attention for their multifunctional therapeutic potential, particularly in the realms of antioxidant and anticancer applications. This review paper synthesizes findings, focusing on the dual role of naphthoquinones in combating oxidative stress and cancer. The unique redox properties of naphthoquinones enable them to effectively neutralize reactive oxygen species (ROS), reducing cellular damage and contributing to the prevention of diseases linked to oxidative stress. Concurrently, these derivatives have shown promise as potent anticancer agents, acting through mechanisms such as apoptosis induction, inhibition of cell proliferation, and interference with critical signalling pathways like PI3K/Akt and MAPK. Advances in the synthesis and structural modification of naphthoquinones have further enhanced their biological activity, making them attractive candidates for targeted cancer therapies. The review highlights key studies from the specified period, showcasing the growing interest in and potential of naphthoquinone derivatives as versatile agents in both antioxidant defences and cancer treatment.