ANTIMICROBIAL AND ACID NEUTRALIZING POTENTIAL OF SELECTED SOLVENT EXTRACT FROM AMARANTHACEAE FAMILY

Abstract

Background and Aim: Medicinal herbs are a rich source of antibacterial agents and can also be utilised as antacids in a variety of Ayurvedic preparations. Hyperacidity is often treated with various artificial antacids. Despite this, plant-derived medications could be effective in developing novel antacids. Thus, the current work was performed to assess the extract of indigenous plants of the Amaranthaceae family for acid-neutralising capacity and antibacterial potential.

Method: The neutralisation capacity was determined in vitro using Fordtran's model titration approach. Antibacterial activity was assessed employing the disc diffusion method, and the minimum inhibitory concentration (MIC) was established using the broth dilution method.

Results: Alternatively, MEAA 100 mg and WEAA 100 mg showed a more powerful neutralizing effect. The largest activity of plant extract in MEAA was found to be at 26.00 mm diameter of ZOI against P. vulgaris followed by 25.00 mm diameter ZOI against E.coli at a concentration of 250 g/disc. Then, there was MEAS which had a ZOI of 21.00 mm against E.coli.

Conclusion: MEAS and MEAA extracts had the maximum acid-neutralizing potential of all the extracts tested. MEAS extract demonstrated the strongest antimicrobial activity against both gram-negative and positive bacteria in vitro.