FLOATING BILAYER TABLET: A REVIEW ON FORMULATION STATERGIES, EVALUATION METHODS AND PHARMACEUTICAL APPLIACATION

Abstract

Floating drug delivery systems (FDDS) are included in the category of gastro-retentive drug delivery systems (GRDDS). By enhancing the drug's buoyancy over stomach fluids, Longer medicine half-lives are made possible by the floating drug delivery system (FDDS). When added to GRDDS, medications that are less soluble in high pH conditions have increased bioavailability and solubility. Drugs with a limited GIT absorption window make excellent candidates for floating drug delivery systems. It works better to treat local infections of the gastrointestinal tract in addition to systemic usage In order to compile the most recent research on floating drug delivery systems (FDDS), this review was created with a focus on the primary mechanism of flotation to achieve stomach retention. The review seeks to give FDDS a general overview., or floating bilayer, including its mechanism, the many technologies needed for its manufacture, a summary of its characterization, and the in vivo performance of GRDDS.