FROM PHARMACEUTICAL PROPERTIES OF BISMUTH DRUGS TO CLINICAL EFFICACY

Abstract

 The article considers the pharmacodynamics, pharmacokinetics and clinical aspects of the use of bismuth tripalium dicitrate, and also conducts a comparative analysis of the physicochemical and structural properties of tablet forms of drugs containing bismuth tripalium dicitrate - the original drug De-Nol (Astellas) and a generic, a new product Ulcavís (KRKA). The demonstrated similar physicochemical properties, in particular the same rate of disintegration of the two tablet forms of bismuth tripalium dicitrate, suggest similar clinical efficacy of the generic and the reference drug.