EXPLORING THE INTERPLAY BETWEEN TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-17 IN THE AUTOIMMUNE THYROID DISEASE

Abstract

     The purpose of this study was to investigate the association between autoimmune thyroid disorders and the interaction between the inflammatory factors interleukin-17 (IL-17) and tumor necrosis factor-alpha (TNF-α). Between May 2023 and October 2023, the study was carried out, with two primary groups  involved :Group for thyroid diseases: 95 people with thyroid problems that have been clinically verified (Hashimotos  49 patients and gravies 46 patients)  .46 participants who seemed healthy made up the control group .All participants had venous blood samples taken, and thyroid hormone levels (TSH, T4, and T3) as well as cytokine levels (TNF-α and IL-17) were measured .The findings demonstrated a statistically significant correlation between autoimmune thyroid disorders and TNF-α and IL-17 levels. Notably, the thyroid had much higher quantities of these cytokinesillness sick group in contrast to the control cohort .These results provide credence to the possibility that TNF-α and IL-17 contribute to inflammation aggravation and the development of autoimmune thyroid diseases. The findings highlight the need for more investigation to fully comprehend the underlying processes driving this association. The work adds to our understanding of the intricate etiology and pathophysiology of autoimmune thyroid diseases by shedding light on the interactions between pro-inflammatory cytokines and these illnesses.