Evaluation of Antipyretic Effects of a Combined Polyherbal Extract of Tulsi, Cumin, Curcumin, And Ginger in Female Rats

Abstract

ABSTRACT

Objective: The study aimed to evaluate the antipyretic effects of a polyherbal extract combining Tulsi (Ocimum sanctum), Cumin (Cuminum cyminum), Curcumin (Curcuma longa), and Ginger (Zingiber officinale) on pyrexia in female rats. The objective was to determine whether the combined extract exhibits a synergistic antipyretic effect, providing a natural alternative to conventional antipyretic drugs.

Materials and Methods: The study involved female Wistar rats, divided into five groups: a control group, a standard drug group (treated with paracetamol), and three test groups treated with different doses of the polyherbal extract. Pyrexia was induced in the rats using Brewer's yeast. The combined extract was prepared by mixing the individual extracts of Tulsi, Cumin, Curcumin, and Ginger in equal proportions. The rectal temperature of the rats was measured at regular intervals post-treatment to assess the antipyretic activity.

Results and Discussion: The polyherbal extract significantly reduced the elevated body temperature in the treated rats compared to the control group. The highest dose of the extract demonstrated an antipyretic effect comparable to that of paracetamol. The results suggest a potential synergistic interaction between the herbs, enhancing their overall antipyretic efficacy. The discussion highlights the relevance of combining these herbs, which have individual medicinal properties, to achieve a potent antipyretic effect.

Conclusion: The study concluded that the combined polyherbal extract of Tulsi, Cumin, Curcumin, and Ginger exhibits significant antipyretic activity in female rats. This polyherbal formulation could serve as an effective natural alternative to synthetic antipyretic drugs, warranting further research for clinical applications.