Potential Nootropic Effects of the Ethanolic Extract of Myristica Fragrans Seeds and Mucuna Pruriens Seed Extract on Scopolamine-Induced Amnesia in Albino Rats

Abstract

This study investigates the behavioral effects of Myristica fragrans and Mucuna pruriens extracts in aged mice, emphasizing spatial learning, memory, and anxiety-related behaviors. In the Morris Water Maze, aged mice treated with the extracts showed compromised spatial learning during the acquisition phase, with increased escape latency. In contrast, Piracetam, a cognitive enhancer, demonstrated positive effects on spatial learning. The Elevated Plus Maze revealed potential influences on locomotor activity and anxiety-like behavior, as both extracts altered time spent in the open arms. Piracetam also impacted locomotion, while scopolamine induced changes consistent with cognitive disruption. Exploring exploratory behavior and anxiety levels through entries into open and closed arms, the extracts' effects were evident, with Piracetam maintaining a profile similar to the control. The step-down passive avoidance test highlighted exacerbated memory deficits with extract treatments, contrasting Piracetam's positive impact on memory retention. Scopolamine-induced impairments validated the paradigm. Overall, the findings underscore potential negative impacts of Myristica fragrans and Mucuna pruriens extracts on spatial learning, memory, and anxiety-related behaviors in aged mice, offering valuable insights into their cognitive effects. Piracetam's contrasting positive influence suggests potential cognitive benefits, positioning it as a reference for cognitive enhancement. This comprehensive analysis contributes to our understanding of the complex behavioral outcomes associated with these plant extracts in the context of aging and cognitionTop of Form