To determine the prevalence of carbapenem resistance among clinical isolates of Acinetobacter baumannii

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Ravneet Pal Singh, Manisha Khandait, Nidhi Goel, Mukesh Sharma

Abstract

Introduction: The prevalence of antibiotic-resistant pathogens has become a major public health concern globally. It is known to cause a wide range of infections, including ventilator-associated pneumonia, bloodstream infections, urinary tract infections, meningitis, and wound infections, particularly in immunocompromised patients or those with prolonged hospital stays. Objectives:  To determine the prevalence of carbapenem resistance among clinical isolates of Acinetobacter baumannii. Methodology:  The prospective observational study was conducted for 24 months and jointly in the Department of Microbiology at SGT University, Gurugram, and the Department of Microbiology at Pt. B. D. Sharma PGIMS, Rohtak. Results: Out of the 200 A. baumannii isolates, 82% were resistant to carbapenems, and 4% were resistant to colistin. Most isolates (96%) remained susceptible to colistin.  Conclusion: Colistin remains effective for the majority of CRAB infections, though resistance is emerging.  Ongoing surveillance and careful antibiotic stewardship are essential to managing the spread of resistance in clinical settings.

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