Thiazole Derivatives: Synthesis Strategies, Structural Characterization, and Evaluation of their Functional Properties

Abstract

Thiazole derivatives are a class of heterocyclic compounds that have gained significant attention in medicinal chemistry due to their diverse biological activities and therapeutic potential. This research article provides a comprehensive overview of the synthesis strategies, structural characterization, and evaluation of the functional properties of thiazole derivatives. The thiazole nucleus, a five-membered aromatic heterocycle composed of one nitrogen, one sulfur, and three carbon atoms, serves as a versatile scaffold for drug development. Thiazolo-pyrimidine derivatives were synthesized through one-pot condensation of substituted thiourea in alcoholic KOH, reacting with aromatic aldehyde and α-halo acid. The structure of 5,7-diphenyl-2H-thiazolo[3,2-a] pyrimidin-3(5H)-one was confirmed by FTIR and mass spectral data