Ocular Nanoparticles: Formulation and Characterization for Targeted Drug Delivery Systems

Abstract

Nanoparticles present a promising platform for enhancing ocular drug delivery by overcoming the physiological barriers of the eye. This research investigates the formulation, characterization, and efficacy of various ocular nanoparticles, including liposomes, chitosan, and hydrogels, for targeted drug delivery systems. The study explores key parameters such as drug encapsulation, bioavailability, and retention in ocular tissues, comparing the performance of different nanoparticle formulations in both in vitro and in vivo conditions. Additionally, advanced drug delivery techniques, such as microneedles and polymeric systems, are evaluated for their potential to further improve targeted and sustained drug release to both the anterior and posterior segments of the eye. This comprehensive study provides critical insights into optimizing nanoparticle formulations for future clinical applications.